Analysis of Creatine Kinase-MB, Renal Biochemical Markers and Hematological Parameters among Alcohol Consumers in Oye-Ekiti, Ekiti State

                @article{CRSIJ26000509,
                  author = {Adegbola Abdullahi Adesina, Babajide Adewoyin Adeleke, Boluwatife Samuel Fatokun, Odunayo Iyanuoluwa Oluwasegun, Folorunsho Davies Olumide, Olubodun Olaotan Esther, Aladesuru Sharon Feyisayo, Shittu Roqeebat Mosunmola},
                  title = {Analysis of Creatine Kinase-MB, Renal Biochemical Markers and Hematological Parameters among Alcohol Consumers in Oye-Ekiti, Ekiti State},
                  journal = {Cosmo Research and Science International Journal},
                  year = {2026},
                  volume = {2},
                  number = {2},
                  pages = {1133-1151},
                  issn = {3108-1584},
                  url = {https://cosmorsij.com/published/CRSIJ26000509.pdf},
                  abstract = {Background: Alcohol is widely consumed in Nigeria, but its combined cardiac, renal and haematological effects at community level are poorly documented. This study compared serum creatine kinase-MB (CK-MB), renal markers, electrolytes and haematological parameters between alcohol consumers and non-consumers in Oye-Ekiti. Methods: In this cross-sectional study (January to May 2026), 100 adults (50 alcohol consumers and 50 non-consumers) were recruited. Questionnaire, anthropometric and blood pressure data were collected. Venous blood was analysed for full blood count and serum biochemistry. CK-MB was measured by fluorescence immunoassay, urea, creatinine and uric acid on an automated analyser, and electrolytes by ion-selective electrode; eGFR was calculated. Data were analysed with chi-square, t-test and ANOVA (p < 0.05). Results: Alcohol use was associated with male sex, transport occupations and secondary education (p < 0.01). Consumers had significantly higher CK-MB (5.32 ± 0.96 vs 1.68 ± 0.98 ng/mL), urea, creatinine, sodium, potassium, chloride, packed cell volume, haemoglobin and red cell count, and lower eGFR, uric acid, white cell and platelet counts (p < 0.05). Neutrophil and monocyte percentages were lower, lymphocyte and eosinophil percentages were higher, and red cell indices did not differ. Nine parameters, including CK-MB and creatinine, differed across drinking categories (p < 0.05). Conclusion: Alcohol consumers had higher CK-MB, urea and creatinine, lower eGFR and uric acid, and altered haematological indices than non-consumers, suggesting early cardiac, renal and haematological changes. Community-based screening of high-risk drinkers, particularly commercial drivers and motorcycle riders, merits consideration.},
                  keywords = {Alcohol consumption, creatine kinase-MB, renal function, electrolytes, haematological parameters},
                  month = {September}
        }