@article{CRSIJ26000067,
                  author = {Adigun Musibau Adeleke, Saliu Bolanle Kudirat},
                  title = {In-vivo antidiarrhea assessment of Bacteria Isolates from selected fermented foods in Mitigating Escherichia-Coli-Induced-Diarrhea in Wistar Rats},
                  journal = {Cosmo Research and Science International Journal},
                  year = {2025},
                  volume = {1},
                  number = {4},
                  pages = {84-102},
                  issn = {3108-1584},
                  url = {https://cosmorsij.com/published/CRSIJ26000067.pdf},
                  abstract = {Antibiotic resistance is a major challenge in the control of diarrhea worldwide. And probiotics that could serve to ameliorate these comes with high cost, and its effectiveness is marred by non-compliance due to drug form presentation. In this study, probiotics were investigated in Nigerian indigenous fermented foods. Bacteria were isolated from Ogi, Kunu and Nunu using pour-plate method on MRS agar. Agar well diffusion method was used to screen the isolates for antibacterial activities against the test organism, Escherichia coli (E. coli). Fecal consistency of Wistar rats was the indices used to assess the therapeutic and preventive potentials of the LAB isolates. The isolates were identified using 16SRNA sequencing. Among 128 bacterial isolates, 26 inhibited the test organism with diameter of inhibition zones ranging from 2.00 to 12.00 mm, and 13 of these showed lactic acid bacteria (LAB) properties. All the 13 isolates resolved the diarrhea induced in Wistar rats with the most active Vagococcus fluvialis within 24hrs of administration. Twelve of the isolates were identified as LAB belonging to the genera Enterococcus, Pediococcus, Weisella and Vagococcus. The non-LAB isolate was Bacillus sp. The study concluded that indigenous fermented foods are rich in probiotic LAB that can serve as alternative to antibiotics in the treatment and prevention of diarrhea due to gastrointestinal infections. The study recommends the use of these organisms for the production of fermented foods that could be used as therapeutic and preventive diets for gastrointestinal diseases},
                  keywords = {Antimicrobial, Escherichia coli, infection, lactic acid bacteria, probiotics and therapeutic},
                  month = {January}
        }